Clinical Reviews

Clinical Review: Guidelines address diagnosis, treatment, and monitoring of IBD in adult patients. Background & Rationale Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, presents a significant clinical challenge due to its chronic, relapsing-remitting nature. Optimal management requires a comprehensive approach, integrating accurate diagnosis, appropriate pharmacological interventions, and vigilant monitoring for disease activity […]

Guidance is provided for the safe and effective use of IBD therapies in patients with renal impairment. Background & Rationale Inflammatory bowel disease (IBD) frequently co-exists with chronic kidney disease (CKD), presenting a complex pharmacological challenge. Patients with IBD and concurrent CKD require careful consideration of medication selection and dosing, as renal impairment alters drug […]

Dietary inflammatory index scores did not correlate with endoscopic or biomarker measures of IBD activity. Background & Rationale Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. While genetic predisposition and immune dysregulation are central to IBD pathogenesis, environmental factors, particularly diet, are increasingly recognised […]

Stankey et al., Nature, 2024, 630, 447–456. Genetic locus on chromosome 21q22 regulates macrophage inflammation and is associated with multiple autoimmune diseases. Increasing rates of autoimmune and inflammatory diseases represent a growing threat to human health, compounded by limited treatment efficacy. This study investigated the functional role of a disease-associated genetic locus on chromosome 21q22, […]